Drug delivery agents in human blood flow

Intensive worldwide research efforts are currently being dedicated to explore the potential of synthetic micro- and nanoscopic particles as drug delivery agents (DDAs) in the human vascular system. Our goal is to understand by means of computer simulations the physical multibody interactions between DDAs and the red blood cells which they encounter on their way from the injection needle through the cardiovascular system towards their target organ.

To understand the behavior of DDAs on the mesocsale, it is necessary to investigate simultaneously the microscopic trajectories of many DDAs, their hydrodynamic interactions and collisions with the highly deformable red blood cells, and the resulting macroscopic flow. Modern algorithms together with the power of present-day supercomputers are now able to provide such a complete picture which is very difficult to obtain from an experiment.

Here we use two very different methods: a boundary-integral method and an immersed boundary code which we contributed to the free software package ESPResSo.

 


micro-particles flowing within branching blood vessels

 

Publications

3D tomography of cells in micro-channels
S. Quint, A. F. Christ, A. Guckenberger, S. Himbert, L. Kaestner, S. Gekle and C. Wagner
Appl. Phys. Lett. 111, 103701 (2017) [DOI] [Info]

Selected as cover

A boundary integral method with volume-changing objects for ultrasound-triggered margination of microbubbles
A. Guckenberger and S. Gekle
J. Fluid Mech. (accepted), (2017)

Clustering of microscopic particles in constricted blood flow
C. Bächer, L. Schrack and S. Gekle
Phys. Rev. Fluids 2, 013102 (2017) [DOI] [ pdf] [Info]

Cross-stream migration of asymmetric particles driven by oscillating shear
M. Laumann, P. Bauknecht, S. Gekle, D. Kienle and W. Zimmermann
Europhys. Lett. 117, 44001 (2017) [DOI]

Dispersion of solute released from a sphere flowing in a microchannel
S. Gekle
J. Fluid Mech. 819, 104-120 (2017) [DOI] [ pdf] [Info]

Hydrodynamic mobility of a solid particle near a spherical elastic membrane. II. Asymmetric motion
A. Daddi-Moussa-Ider, M. Lisicki and S. Gekle
Phys. Rev. E 95, 053117 (2017) [DOI] [ pdf]

Hydrodynamic mobility of a solid particle nearby a spherical elastic membrane: Axisymmetric motion
A. Daddi-Moussa-Ider and S. Gekle
Phys. Rev. E 95, 013108 (2017) [DOI] [ pdf] [Info]

Hydrodynamic mobility of a sphere moving on the centerline of an elastic tube
A. Daddi-Moussa-Ider, M. Lisicki and S. Gekle
Phys. Fluids 29, 111901 (2017) [DOI]

Measurement of the magnetic moment of single Magnetospirillum gryphiswaldense cells by magnetic tweezers
C. Zahn, S. Keller, M. Toro-Nahuelpan, P. Dorscht, W. Groß, M. Laumann, S. Gekle, W. Zimmermann, D. Schüler, and H. Kress
Sci. Rep. 7, 3558 (2017) [DOI]

Mobility of an axisymmetric particle near an elastic interface
A. Daddi-Moussa-Ider, M. Lisicki and S. Gekle
J. Fluid Mech. 811, 210-233 (2017) [DOI] [ pdf] [Info]

Slow rotation of a spherical particle inside an elastic tube
A. Daddi-Moussa-Ider, M. Lisicki and S. Gekle
Acta Mechanica (accepted), (2017) [DOI]

Theory and algorithms to compute Helfrich bending forces: A review
A. Guckenberger and S. Gekle
J. Phys. Cond. Mat. 29, 203001 (2017) [DOI] [ pdf] [Info]

Elastic cell membranes induce long-lived anomalous thermal diffusion on nearby particles
A. Daddi-Moussa-Ider, A. Guckenberger and S. Gekle
Phys. Rev. E 93, 012612 (2016) [DOI] [ pdf] [Info]

Hydrodynamic interaction between particles near elastic interfaces
A. Daddi-Moussa-Ider and S. Gekle
J. Chem. Phys. 145, 014905 (2016) [DOI] [ pdf] [Info]

Mechanical behaviour of micro-capsules and their rupture under compression
A. Ghaemi, A. Philipp, A. Bauer, K. Last, A. Fery and S. Gekle
Chem. Eng. Sci. 142, 236-243 (2016) [DOI] [Info]

One-component dual actuation: Poly(NIPAM) can actuate to stable 3D forms with reversible size change
L. Liu, A. Ghaemi, S. Gekle and S. Agarwal
Adv. Mater. 1-5 (2016) [DOI] [Info]

On the bending algorithms for soft objects in flows
A. Guckenberger, M. P. Schraml, P. G. Chen, M. Leonetti and S. Gekle
Comp. Phys. Comm. 207, 1-23 (2016) [DOI] [ pdf] [Info]

Particle mobility between two planar elastic membranes: Brownian motion and membrane deformation
A. Daddi-Moussa-Ider, A. Guckenberger and S. Gekle
Phys. Fluids 28, 071903 (2016) [DOI] [ pdf]

Strongly accelerated margination of active particles in blood flow
S. Gekle
Biophys. J. 110, 514-520 (2016) [DOI] [ pdf] [Info]

 

Bachelor and Master Theses

Analytical description of nanoparticle motion near an elastic membrane
R. Benelli
BSc thesis (2016)

Cross-streamline migration of an asymmetric capsule in linear shear flow
P. Bauknecht
MSc thesis (2016)

Particle and red blood cell dynamics in microcirculatory blood flow
C. Bächer
MSc thesis (2016)

Polymer chains How they influence the red blood cell motion
C. Bezold
BSc thesis (2016)

Hydrodynamic mobility of anisotropic particles using lattice boltzmann method
C. Werner-Schmolling
BSc thesis (2015)

Implementation of an advanced bending model for red blood cells with application to Stokes flow
M. Schraml
BSc thesis (2015)

Simulation of red blood cells and microbubbles in infinite and periodic Stokes flow
A. Guckenberger
MSc thesis (2015)

Cross-streamline migration of an asymmetric capsule in linear shear flow
P. Bauknecht
BSc thesis (2014)

Diffusion properties of spherical cells gradually decreasing rigidity
F. Dietl
BSc thesis (2014)

Flux simulations in different geometries using lattice Boltzmann method
L.Schrack
BSc thesis (2014)

Nanoparticle diffusion near elastic membranes and in cell suspensions
V. Forster
MSc thesis (2014)

Particle migration in blood-like flows
A. Schnapp
BSc thesis (2014)

Investigation of the Boundary Integral Method for Stokes Flow
M. Hahn
MSc thesis (2013)

University of Bayreuth   -